Tue | Dec 6, 2016

A look at the proposal to make babies from 3 persons

Published:Wednesday | February 4, 2015 | 12:00 AM

LONDON (AP):

British lawmakers in the House of Commons voted yesterday to legalise the creation of babies made from the DNA of three people. The bill now must go to the House of Lords before it becomes law.

Here are some questions and answers about the proposed techniques and the controversy surrounding them.

WHY ARE SCIENTISTS PROPOSING THIS?

The new fertility techniques aim to help women who are carriers of mitochondrial disease from passing it on to their children. Mitochondria are the energy-producing structures outside of a cell's nucleus, and defects in them can result in degenerative diseases, including muscular dystrophy, problems with the heart and kidneys, severe muscle weakness, epilepsy and mental retardation.

Scientists would remove the nucleus DNA from the egg of a prospective mother and insert it into a donor egg from which the nucleus DNA has been removed. That can be done either before or after fertilisation. The resulting embryo has nucleus DNA from its parents but mitochondrial DNA from the donor. Scientists say the DNA from the donor egg is less than one per cent of the resulting embryo's genes.

WHO IS OPPOSED TO THIS?

The Catholic Church has long opposed any artificial reproductive techniques that include fertilisation or the destruction of embryos. Last week, the Church of England voiced concern that there had not been enough scientific study or consultation of the techniques.

Other critics say that because the genetic change made to the embryo or egg will be a permanent one that is passed on, it's impossible to know what impact they will have on future generations and if there are any safety problems.

IS THIS LIKE MAKING GENETICALLY MODIFIED FOODS?

No. To make genetically modified foods, scientists select individual genes to be transferred from one organism into another. Most of the genetically modified foods on the market are aimed at making crops less vulnerable to pesticides or plant diseases.

In the techniques used to help women with mitochondrial disease, no genes are inserted into the egg or the embryo.

HOW WIDELY WOULD THE MITOCHONDRIAL TECHNIQUES BE USED?

Experts estimate only about a dozen British women would be considered for this every year and that some women may choose other ways to have children, such as egg donation or adoption. Clinics that offer the techniques will have to apply for a special licence and any children born afterward will be closely monitored for potential health problems.

Experts estimate the first baby born from these techniques could come within the next three years.

IS THIS ALLOWED ANYWHERE ELSE?

Not legally. There are no mitochondria replacement treatments approved by the United States Food and Drug Administration. Last year, the US agency met to discuss the techniques proposed in the United Kingdom. Scientists in the US said it's too soon to use them in humans, although monkeys have been produced using one of the techniques.